Archives

ECCMID 2019 in Amsterdam

We will be at ECCMID 2019 with a poster contribution and as an exhibitor. The poster is on a novel cUTI mouse model and the application of PK/PD modelling to derive the required effect in the mouse model that translates to clinical response. We used historical Levofloxacin data to establish this animal-human translation. Visit us at our booth to learn more how we can support your preclinical, translational and clinical program with PK/PD modelling. … Read the rest

 

LYO-X joint BEAM to Fight Antimicrobial Resistance

LYO-X joint the BEAM (Biotech companies in Europe combating AntiMicrobial Resistance) alliance, a strong Network of ~ 50 European biopharmaceutical companies committed to developing innovative products to fend-off antibiotic-resistant pathogens.

We have continuously expanded our support of biotech companies with PK/PD modelling and SystemsPharmacology to translate their antibiotics more effectively to patients. Helping biotechnology companies to succeed and bringing new antibiotics to patients is something we feel really committed to.

By joining BEAM we hope to help even more biotechs to bring their drugs to patients and to increase the awareness of PK/PD modelling as a tool for efficient antibiotics drug development.… Read the rest

 

‘In-silico Drug Development, Modelling & Simulation’ at the University of Freiburg

LYO-X will give a lecture + hands on seminar on ‘In-silico Drug Development, Modelling & Simulation’ at the University of Freiburg for Pharmacy Master Students. This is together with Dr. Regenold GmbH who will be covering complementary topics on preclinical and clinical drug development . We are looking forward to engage the students and to give them a real world perspective on how in silicon methods are used today to develop novel drugs.… Read the rest

 

Poster presentation at PAGE 2018

Systems Pharmacology model of peripheral serotonin production proposing two different synthesis compartments with markedly different release rates into blood. Link to abstract

M. Machacek (1), L. Renaud (1), C. Kohl (2), M. Vercauteren (2), L. Remen (2), R. Welford (2). (1) LYO-X GmbH, Ringstrasse 9, 4123 Allschwil, Switzerland. (2) Idorsia Pharmaceuticals Limited, Hegenheimermattweg 91, 4123 Allschwil, Switzerland… Read the rest

 

12th Basel M&S Seminar: ‘Modelling … AND SIMULATION’

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LATSIS Symposium ETH ZURICH on Personalised Medicine

LYO-X is sponsoring the LATSIS Symposium on Personalised Medicine to be held at the ETH Zurich June 27–29 2016. Personalised medicine has a number of quite attractive advantages. Treatments tailored to the individual patient, for example by therapy selection based on diagnostic tools or by individualised dosing, should improve the effect, lower side effects and lower costs by avoiding ineffective treatments. It appears to be an obvious solution given the situation we have today in the health care system. However, despite the advantages most drugs are still developed as a one-fits-all solution without any diagnostic tools.… Read the rest

 

20. PK/PD Expert Meeting

We were very kindly invited to the 20. Pharmacokinetics/Pharmacodynamics Expert Meeting in Berlin April 14th – 16th 2016. It will be a great opportunity to meet the German PKPD experts. There is an attractive agenda including:

  • Systems Pharmacology
    Methods, Applications, Opportunities and Challenges
  • Dose Finding in Phase II for Confirmatory Clinical Trials
    Overview, Methods, Good Practices and Examples
  • PK/PD of Locally Applied Drugs
    Considerations for (Sub-)Cutaneous and Ocular Administration of Pharmaceuticals

Of course we are in the Systems Pharmacology session where we will talk about the “Introduction to Concepts and Methods of Systems Pharmacology”.… Read the rest

 

ACoP6

We will be at ACoP6 with our partner Lixoft meeting the pharmacometrics community and teaching at the Monolix Suite workshop.
I’m looking very much forward to the event. It will be great to meet all my friends and colleagues especially everyone living in the US who I have not seen for quite a while.
I’m going to talk about Simulx on day two of the Monolix Suite workshop which I’m especially proud of. It is such an elegant and powerful solution for NLME simulations.… Read the rest

 

Why Investing Millions in Generating Data?

LYO-X will be at the Life Science Forum Basel this coming Thursday, June 18th. We will address the very relevant question “Why Investing Millions in Generating Data?” and show “How to Use Systems Pharmacology to Make the Most of Your Data”. Join us at this event with a very exciting program. The event is at the Pharmazentrum/Biozentrum of the University of Base and starts midday. For more details see the PROGRAM.… Read the rest