Strategic consulting and PK/PD modelling services dedicated to preclinical and clinical biotherapeutics development
Mission
We support the translation of innovation into pharmacological concepts and therapies. We believe that the most innovative therapeutic ideas deserve the best development tools. We use Systems Pharmacology as a key tool to maximize the success of your preclinical program, clinical study or registration.
Services
Our services includes consultancy and implementation of systems pharmacology and PK/PD modelling for target assessment, format selection, compound design, candidate selection, design and analysis of preclinical PK/PD and GLP toxicology studies, first in human dose selection, paediatric dose selection and dose / regimen finding studies.
Why choose us
Our methods have been successfully applied in global pharmaceutical companies with tangible results including patents. We have the unique tested expertise developing bi-specifics, antibody-drug conjugates, scFv’s, nanobodies, cell based therapies to provide tailored support for your program.
Partners
LYO-X is member of the iBx Network. We provide integrated consulting in toxicology, pathology, preclinical and clinical pharmacology and regulatory strategies.
LYO-X is partnering with Lixoft to provide you access to Monolix the scientifically and technologically most advanced software for preclinical and clinical data analysis.
Learn more why Systems Pharmacology is a critical tool for the development of novel Biologics
Systems Pharmacology: An Industry Perspective
Matthias Machacek
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‘In-silico Drug Development, Modelling & Simulation’ at the University of Freiburg
LYO-X will give a lecture + hands on seminar on ‘In-silico Drug Development, Modelling & Simulation’ at the University of Freiburg for Pharmacy Master Students. This is together with Dr. Regenold GmbH who will be covering complementary topics on preclinical and clinical drug development . We are looking forward to … Read More
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Postdoctoral position
Automated skin lesion detection and severity classification using image analysis and machine learning. Unique opportunity to boost your career in Switzerland as an outstanding researcher. Application deadline: July 15. 2018. See our career website for more details.
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Poster presentation at PAGE 2018
Systems Pharmacology model of peripheral serotonin production proposing two different synthesis compartments with markedly different release rates into blood. Link to abstract M. Machacek (1), L. Renaud (1), C. Kohl (2), M. Vercauteren (2), L. Remen (2), R. Welford (2). (1) LYO-X GmbH, Ringstrasse 9, 4123 Allschwil, Switzerland. (2) Idorsia Pharmaceuticals … Read More