Comprehensive mathematical model of the alternative complement pathway describing in vitro experimental- and clinical-data

We recently published a comprehensive mathematical model of the alternative complement pathway in the PLOS Computational Biology journal. The model includes all known positive and negative regulators of the pathway and has been tested on a comprehensive set of in vitro experimental data and clinical data. As such its an exciting tool to probe the pathway model to predict the outcome of different pharmaceutical interventions on key bio- and pharmacodynamic markers.