Format Selection and Compound Design

Format selection has an impact on half-life, tissue accessibility, effector functions. Thus for format selection the target kinetics, site of expression and indication have to be factored in to assess the potential for a best in class compound through optimal PK/PD properties: maximal target inhibition at low doses and dose frequencies.

Investigation of particular cases e.g. bi-phasic dose response curve for cross-linking bi-specifics or target mediated drug disposition (TMDD) for cell surface targets.