We will be at ECCMID 2019 with a poster contribution and as an exhibitor. The poster is on a novel cUTI mouse model and the application of PK/PD modelling to derive the required effect in the mouse model that translates to clinical response. We used historical Levofloxacin data to establish this animal-human translation. Visit us at our booth to learn more how we can support your preclinical, translational and clinical program with PK/PD modelling. … Read the rest
Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4
Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, William G. Darby, Chris G. Hosking, Lionel Renaud, Matthias Machacek, Peter Lloyd, Arne Skerra & Michael Foley. mAbs, 2019
Single domain antibodies that combine antigen specificity with high tissue penetration are an attractive alternative to conventional antibodies. However, rapid clearance from the bloodstream owing to their small size can be a limitation of therapeutic single domain antibodies. Here, we describe and evaluate the conjugation of a single domain i-body, AD-114, which targets CXCR4, to a panel of half-life extension technologies including a human serum albumin-binding peptide, linear and branched PEG, and PASylation (PA600).… Read the rest
Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab Christine Voors-Pette, Kristell Lebozec, Peter Dogterom, Laurie Jullien, Philippe Billiald, Pauline Ferlan, Lionel Renaud, Olivier Favre-Bulle, Gilles Avenard, Matthias Machacek, Yannick Plétan, Martine Jandrot-Perrus. Arterioscler Thromb Vasc Biol. 2019;39:956-964.… Read the rest
LYO-X joint the BEAM (Biotech companies in Europe combating AntiMicrobial Resistance) alliance, a strong Network of ~ 50 European biopharmaceutical companies committed to developing innovative products to fend-off antibiotic-resistant pathogens.
We have continuously expanded our support of biotech companies with PK/PD modelling and SystemsPharmacology to translate their antibiotics more effectively to patients. Helping biotechnology companies to succeed and bringing new antibiotics to patients is something we feel really committed to.
By joining BEAM we hope to help even more biotechs to bring their drugs to patients and to increase the awareness of PK/PD modelling as a tool for efficient antibiotics drug development.… Read the rest
LYO-X will give a lecture + hands on seminar on ‘In-silico Drug Development, Modelling & Simulation’ at the University of Freiburg for Pharmacy Master Students. This is together with Dr. Regenold GmbH who will be covering complementary topics on preclinical and clinical drug development . We are looking forward to engage the students and to give them a real world perspective on how in silicon methods are used today to develop novel drugs.… Read the rest
Automated skin lesion detection and severity classification using image analysis and machine learning. Unique opportunity to boost your career in Switzerland as an outstanding researcher. Application deadline: July 15. 2018. See our career website for more details.… Read the rest
Systems Pharmacology model of peripheral serotonin production proposing two different synthesis compartments with markedly different release rates into blood. Link to abstract
M. Machacek (1), L. Renaud (1), C. Kohl (2), M. Vercauteren (2), L. Remen (2), R. Welford (2). (1) LYO-X GmbH, Ringstrasse 9, 4123 Allschwil, Switzerland. (2) Idorsia Pharmaceuticals Limited, Hegenheimermattweg 91, 4123 Allschwil, Switzerland… Read the rest
Population pharmacokinetics of CAP7.1 and the effect on total target lesion size in adult patients with biliary tract cancer. Matthias Machacek, Ulrich-Frank Pape, Ulrich Keilholz, Marianne Sinn, Stefan Kasper, Johannes Meiler, Arndt Vogel, Lothar Mueller, Karel Caca, Jan Kuhlmann, Oswald Burkhard, Victor Rodriguez Laval, Glyn Steventon, Nalan Utku, Holger Jansen; LYO-X GmbH, Allschwil, Switzerland; Department of Internal Medicine, Charité-Universitätsmedizin, Berlin, Germany; Department for Hemato-Oncology, Comprehensive Cancer Center, Charité-University Medicine, Berlin, Germany; Medizinischen Klinik m.S. Hepatologie und Gastroenterologie, Berlin, Georgia; Department of Medical Oncology, West German Cancer Center, University Hospital Essen, Essen, Germany; Hannover Medical School, Hannover, Germany; Onkologie Praxis, Leer, Germany; Klinikum Ludwigsburg, Ludwigsburg, Germany; Department of Medicine II, University Hospital Freiburg, Freiburg, Germany; Onkologie Praxis, Worms, Germany; Instutut für Radiologie, Berlin, Germany; University of Surrey, Surrey, United Kingdom; CellAct, Dortmund, Germany; CellAct Pharma GmbH, Dortmund, Germany. … Read the rest