Dr. Matthias Machacek, Managing Director
Dr. Machacek is an experienced drug development professional with extensive international experience in global pharmaceutical industries. He managed a global group with the responsibility for providing modeling support for preclinical biologics programs at major global pharmaceutical company. Activities included target validation, compound design, candidate selection, PK/PD and GLP toxicology study design and first in human dose selection in respiratory, autoimmune and inflammatory, ophthalmology, cardiovascular, oncology and musculoskeletal disease areas. He obtained 2 patents for innovative dosing strategy and 1 patent for a target identification. He contributed to IND submissions and briefing books and participated at FDA and EMA meetings to justify dosing based on modeling.